What are the alternatives for a malaria vaccine after the RTS,S Essay

What are the alternatives for a malaria vaccine after the RTS,S disappointments - Essay Example f the fact that a vaccine based on blood-stage antigens could put restrictions or arrest the spread of disease, and the causes of death in recipients even if it is does not prevent infections. The crossing point between host and parasite entail composite molecular interactions that are associated with the identification and attack of the host cells or acquiring nutrients from the cytoplasm or the plasma milieu. It entails working by use of alpha –helical coiled coil domains of some proteins that are expected to be available in the parasite during the erythrocytic stage those peptides are expected to be similar in their structural nature to the native epitopes. It is widely known as the transmission-blocking vaccine which is designed to produce an immune response in human hosts, as a result of which the growth of the parasite into mosquito vector and the ultimate transmission is bound to be fruitless. The generation of malaria vaccine has not been an easy task due to the nature of the parasite. In essence, it has a complicated life cycle that has rapid amplification once it has entered the human body posing a great predicament. The continuous resistance of both the parasite and the anti malaria drugs has made the development of an effective malaria vaccine a global priority with an ideal malaria vaccine expected to stimulate natural acquired immunity in communities where malaria is endemic. Malaria, is a mosquito-borne, protozoal illness, identified as a parasite disease with the vector been a mosquito in early 19th century. Its infection manifest in human beings as a result of infection by Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale or Plasmodium malariae with Plasmodium falciparum that is responsible for mass clinical cases and mortalities. In essence, the female anopheles mosquito transmits the plasmodium parasite. According to Coleman and Tsongalis 2009, it leaves the parasite in the human blood in the process of feeding on the

CRITIQUE OF QUANTITATIVE ARTICLE Research Paper Example | Topics and Well Written Essays - 500 words

CRITIQUE OF QUANTITATIVE ARTICLE - Research Paper Example The researchers conducted a qualitative study in order to evaluate inadvertent perioperative hypothermia knowledge among nurses. This means that the study applied normal quantitative techniques and research design. Quantitative designs are useful when a researcher intends to measure the relationship between two or more variables. In this case, the outcome needs to have experimental significance. The study considered is descriptive indicating that the researcher did not utilize an experimental approach. The research design fails to satisfy the requirements of a quantitative study. Choice of dependent and independent variables also fails to comply with quantitative requirements. This implies that the study would be effective if it was conducted from a quantitative approach. Indeed, the quantitative approach does not answer some critical questions that are of interest to the audience. For instance, the study does not explain lack of inadvertent perioperative hypothermia knowledge among practicing nurses. Successful descriptive studies, utilizes large the sample size (Evans & Kenkre, 2006). This indicates that the researcher required hundreds of subjects to minimize errors and biasness. However, the study received only 130 responses from the 168 participants selected for the study. This was a fair outcome since the respondent provided quality data. Participants for the study were selected from nurses attending the Irish Anesthetic and Recovery Nurses Association Annual Conference. The study seems to have attracted participants of the right caliber as required in the initial proposal. The study also followed an acceptable protocol to request consent and participation of the nurses. Voluntary participation and completion of question contained in the questionnaire indicates a high level of consent among the participants. Questionnaires were the main data collection tools for the study. The questionnaires had nine questions that were designed to